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pentobarbital will decrease the extent or impact of abemaciclib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of abemaciclib with sturdy CYP3A4 inducers decreases plasma focus of abemaciclib and its metabolites.pentobarbital will lower the level or result of fosamprenavir by impac